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王冠
发布人:生工学院网站管理员  发布时间:2021-07-09   动态浏览次数:3219


王 冠



生物工程专业:硕士生导师

生物化工专业:硕士生导师

生物与医药专业(生物工程领域):硕士生导师

  

王冠,工学博士,生物反应器工程国家重点实验室讲师,硕士生导师。入选上海市青年科技启明星2021A类),华东理工大学青年英才培育计划2020 A类),生物工程学青椒计划2019年)。2018年毕业于华东理工大学获生物化工专业工学博士学位,同年进入华东理工大学轻工技术与工程流动站从事博士后研究工作,20207月出站担任教职。

    近年来,依托生物反应器工程国家重点实验室国家生化工程技术研究中心(上海),在细胞代谢模型指导发酵过程动态调控新技术以及模型化视角下工业生物过程理性放大新方法开发等方面开展了系统性研究工作。作为项目负责人主持国家自然科学基金青年基金、国家重点研发计划子课题、上海市科技创新行动计划启明星项目、上海市科技创新行动计划自然科学基金、上海市博士后日常经费专项基金等项目;作为主要项目骨干参与中国-荷兰国际科技合作专项多项国家自然科学基金项目等。2015年赴荷兰代尔夫特理工大学(Delft University of Technology)皇家科学院院士Prof. Joseph J. Heijnen课题组开展合作项目Bioreactor scale-down相关实验以及定量代谢物组学分析技术交流与学习。近年来,在Trends in Biotechnology, Biotechnology and Bioengineering, Microbial Biotechnology, Biotechnology Journal, Journal of Biotechnology等本领域顶级及权威期刊上发表SCI收录论文20余篇,第一或通讯作者14篇,英文专著章节2章,申请中国发明专利1项。

研究方向:

1. 工业规模生物反应器流场缩放(scale-down)与细胞代谢机制解析

大规模生物反应器细胞运动轨迹模拟与多组学整合分析

2. 大数据-代谢模型驱动下的生物过程智能优化与调控

基于大数据-机理融合驱动模型实现发酵过程跨尺度智能优化与调控

3. 肿瘤细胞代谢与靶向治疗

靶向肿瘤细胞代谢并结合肿瘤药物定点智能控释系统实现自杀式肿瘤治疗

4. 哺乳动物细胞培养过程优化与放大

基于过程分析技术(PAT)的哺乳动物细胞灌注流工艺开发与应用

主持或参加的科研项目或基金:

1. 上海市青年科技启明星计划A21QA1402400),2021/7-2024/640万,主持

2.“绿色生物制造国家重点研发计划子课题2021YFC2101103),2021/7-2024/695.3万,主持

3.“绿色生物制造国家重点研发计划子课题2021YFC2101005),2021/7-2025/650万,主持

4. 国家自然科学基金青年基金项目31900073),2020/1-2022/1224万元,主持

5. 上海市自然科学基金项目19ZR1413600),2019/7-2022/620万元,主持

6. 上海市博士后日常经费2018/1-2019/1216万,主持

7. 华东理工大学青椒计划2020/1-2021/1215万,主持

8. 华东理工大学基本科研业务费专项基金 2018/1-2018/126万,主持

9. 上海市生物过程工程服务平台能力建设专项 2018/6-2021/5150万,参加

10. 国家自然科学基金面上基金项目2018/1-2021/1264万元,参加

11. 国家自然科学基金青年基金项目2016/1-2018/1221万元,参加

12. 中国-荷兰国际科技合作计划2013/4-2017/3294万元,参加

本科与研究生教学:

1. 本科生专业必修课,《实验数据统计分析》,16学时,1学分;

2. 本科生专业必修课,《生物反应工程原理》(全英文),48学时,3学分;

3. 本科生专业必修课,《发酵工程》,16/48学时,3学分;

4. 研究生专业核心课,《生物反应器工程》,32/64学时,4学分;

5. 研究生专业选修课,《生物反应工程》(全英文),32学时,2学分。

代表性论文(*通讯作者):  

1一作或通讯论文

1. Qi Yang, Wenli Lin, Jiawei Xu, Nan Guo, Jiachen Zhao, Gaoya Wang, Yongbo Wang, Ju Chu, and Guan Wang*. Changes in Oxygen Availability during Glucose-Limited Chemostat Cultivations of Penicillium chrysogenum Lead to Rapid Metabolite, Flux and Productivity Responses.Metabolites, 2022, 12(1), 45.

2. Lin Wang, Xueting Wang, Tong Wang, Yingping Zhuang, and Guan Wang*. Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model. Bioresources and Bioprocessing,2021, 8(1), 1-21.

3. Xinxin Wang, Jiachen Zhao, Jianye Xia*, Guan Wang*, Ju Chu and Yingping Zhuang. Impact of Altered Trehalose Metabolism on Physiological Response of Penicillium chrysogenum Chemostat Cultures during Industrially Relevant Rapid Feast/Famine Conditions. Processes, 2021, 9(1), 118-134.

4. Guan Wang*, Cees Haringa, Henk Noorman, Ju Chu, and Yingping Zhuang*. Developing a Computational Framework To Advance Bioprocess Scale-Up. Trends in Biotechnology, 2020, 38(8), 846-856.

5. Guan Wang, Cees Haringa, Wenjun Tang, Henk Noorman, Ju Chu*, Yingping Zhuang*, and Siliang Zhang. Coupled metabolic-hydrodynamic modeling enabling rational scale-up of industrial bioprocesses. Biotechnology and Bioengineering, 2020, 117, 844-867.

6. Tong Wang, Lin Wang, Guan Wang*, and Yingping Zhuang*. Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers. Bioresources and Bioprocessing, 2020,7(1), 1-34.

7. Jiachen Zhao, Guan Wang*, Ju Chu, and Yingping Zhuang. Harnessing microbial metabolomics for industrial applications. World Journal of Microbiology and Biotechnology, 2020, 36(1), 1-18.

8. Guan Wang*, Ju Chu, Yingping Zhuang*, Walter van Gulik, and Henk Noorman. A dynamic model-based preparation of uniformly-13C-labeled internal standards facilitates quantitative metabolomics analysis of Penicillium chrysogenum. Journal of Biotechnology, 2019, 299, 21-31.

9. Guan Wang, Xinxin Wang, Tong Wang, Walter van Gulik, Henk J. Noorman, Yingping Zhuang*, Ju Chu*, and Siliang Zhang. Comparative fluxome and metabolome analysis of formate as an auxiliary substrate for penicillin production under glucose-limited cultivation of Penicillium chrysogenum. Biotechnology Journal, 2019, 14(10), 1900009.

10. Guan Wang, Junfei Zhao, Xinxin Wang, Tong Wang, Yingping Zhuang*, Ju Chu*, Siliang Zhang, Henk J. Noorman. Quantitative metabolomics and metabolic flux analysis reveal impact of altered trehalose metabolism on metabolic phenotypes of Penicillium chrysogenum in aerobic glucose-limited chemostats, Biochemical Engineering Journal, 2019, 146: 41-51.

11. Guan Wang, Baofeng Wu, Junfei Zhao, Cees Haringa, Jianye Xia, Ju Chu*, Yingping Zhuang, Siliang Zhang, Joseph J. Heijnen, Walter van Gulik, Amit T. Deshmukh, Henk J. Noorman*. Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels, Biotechnology and Bioengineering, 2018, 115: 114-125.

12. Guan Wang, Junfei Zhao, Cees Haringa, Wenjun Tang, Jianye Xia, Ju Chu*, Yingping Zhuang, Siliang Zhang, Amit T. Deshmukh, Walter van Gulik, Joseph J. Heijnen, Henk J. Noorman. Comparative performance of different scale-down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis, Microbial Biotechnology, 2018, 11: 486-497.

12. Guan Wang, Wenjun Tang, Jianye Xia, Ju Chu*, Henk J. Noorman, Walter van Gulik. Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses, Engineering in Life Sciences, 2015, 15: 20-29.

13. Guan Wang, Ju Chu*, Henk J. Noorman, Jianye Xia, Wenjun Tang, Yingping Zhuang, Siliang Zhang. Prelude to rational scale-up of penicillin production: a scale-down study, Applied Microbiology and Biotechnology, 2014, 98: 2359-2369.

2合著论文

1. Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, and Yingping Zhuang*. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains. Chinese Journal of Chemical Engineering, 2021, 30, 178-184.

2. Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang*, Ju Chu, Yufei Sui, and Yingping Zhuang*. Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation. Microbial Cell factories, 2020, 19: 1-14.

3. Shaohuang Shen, Guan Wang, Ming Zhang, Yin Tang, Yang Gu, Weihong Jiang, Yonghong Wang* and Yingping Zhuang*. Effect of temperature and surfactant on biomass growth and higher-alcohol production during syngas fermentation by Clostridium carboxidivorans P7. Bioresources and Bioprocessing, 2020, 7(1), 1-13.

4. Cees Haringa, Wenjun Tang, Guan Wang, Amit T. Deshmukh, Wouter A van Winden, Ju Chu, Walter M van Gulik, Joseph J Heijnen, Robert Mudde and Henk J Noorman*. Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: Towards rational scale-down and design optimization, Chemical Engineering Science, 2018, 175: 12-24.

5. Wenjun Tang, Amit T. Deshmukh, Cees Haringa, Guan Wang, Walter van Gulik, Wouter van Winden, Matthias Reuss, Joseph J. Heijnen, Jianye Xia, Ju Chu* and Henk J. Noorman. A 9-pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum, Biotechnology and Bioengineering, 2017, 114: 1733-1743.

6. 王冠,田锡炜,夏建业,储炬,张嗣良,庄英萍*. 大数据-模型混合驱动下生物过程优化与放大的新机遇与挑战. 生物工程学报2021, 37(3), 1004-1016.

7. 朱紫瑜,王冠,庄英萍*. 大规模哺乳动物细胞培养工程的现状与展望. 合成生物学2021, 2, 1-23.

8. 田锡炜,王冠,张嗣良,庄英萍*. 工业生物过程智能控制原理和方法进展. 生物工程学报2019, 35(10), 2014-2024.

9. 赵骏飞, 王冠, 吴宝峰, 储炬*, 张嗣良. 基于土壤农杆菌转化法高效构建高产产黄青霉tps1 tps2 敲除菌株. 中国医药工业杂志2017, 48(9), 1293-1301.

撰写专著:

1. Guan Wang*, Cees Haringa, Ju Chu, Yingping Zhuang, Wouter van Winden and Henk Noorman. Harnessing dynamic metabolomics for bioprocess prediction and beyond.Handbook of Molecular Biotechnology, CRC press, 2022, in press.

2. Xia JY, Guan Wang, Lin JH, Wang YH, Chu J, Zhuang YP, Zhang SL*. Advances and practices of bioprocess scale-up. Bioreactor Engineering Research and Industrial Applications II: Springer. 2015, p 137-151.

发明专利:

王冠, 王彤, 王琳, 欧阳立明, 庄英萍. 一种多细胞肿瘤球及其高通量制备方法CN110616185A

联系方式:

上海市徐汇区梅陇路130邮编200237

办公室:实验十八楼411

电话:021-64250719

邮箱:guanwang@ecust.edu.cn